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The standard analysis can in fact produce a bit improved statistical precision.13 This may apply, by way of example, if two or maybe more cases as well as their matched controls all have identical values for his or her matching aspects; then combining them into an individual stratum creates an estimator with lower variance and no considerably less validity14 (as indicated by the slightly narrower confidence interval for your common modified analysis (table one⇑) as opposed Together with the pair matched analysis (desk 2⇑). This especially occurs simply because combining strata with identical values with the matching elements (eg, if two case-control pairs all concern Females aged 55-59 a long time) may possibly imply that fewer information are discarded (which is, tend not to add to your analysis) as a consequence of strata in which the case and Regulate contain the exact exposure standing.

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Most different cases – Cases which are various on all the unbiased variables, besides the one among interest into the researcher

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In certain situations, this Handle may make no distinction to the leading exposure outcome estimate—eg, If your matching variable is unrelated to exposure. Even so, if there is an Affiliation among the matching issue plus the exposure, then matching will introduce confounding that should be controlled for while in the analysis.

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